NOI - Acquisition of a Sonication Device for Amyloid Seeding Experiments
Overview
Buyer
Place of Performance
NAICS
PSC
Set Aside
Original Source
Timeline
Qualification Details
Fit reasons
- NAICS alignment with historical contract wins in similar service areas.
- Scope strongly matches core technical capabilities and delivery model.
Risks
- Past performance thresholds may require one additional teaming partner.
- Potential clarification needed on staffing minimums before bid/no-bid.
Next steps
Validate eligibility requirements, assign capture owner, and schedule partner outreach to confirm teaming strategy before submission planning.
Quick Summary
The National Heart, Lung, and Blood Institute (NHLBI) intends to award a sole source purchase order to Hologic Sales and Service, LLC for a sonication device to support amyloid seeding experiments. This device is critical for research into neurodegenerative diseases by enabling standardized preparation of pre-formed fibrils (PFFs). While this is a Notice of Intent (NOI) to sole source, interested parties may submit capability statements.
Scope of Requirement
NHLBI requires one (1) sonication device capable of highly controlled and reproducible sonication of small-volume biological samples. The device will be used to generate standardized pre-formed fibrils (PFFs) for ongoing research at the Laboratory of Protein Conformation and Dynamics in Bethesda, MD.
Key Technical Requirements
The required device must feature:
- Indirect (bath-based) sonication without direct probe contact.
- Capability to process samples in sealed tubes to prevent contamination.
- Adaptive or controlled cavitation for uniform energy distribution.
- Continuous sample rotation during sonication.
- Integrated temperature control to prevent sample degradation.
- Compatibility with small sample volumes (approx. 20 µL to 2 mL).
- Ability to process multiple samples simultaneously under identical conditions.
- Demonstrated capability for reproducible preparation of PFFs, supported by scientific literature.
Contract Details & Timeline
- Opportunity Type: Presolicitation / Notice of Intent to Sole Source
- Product/Service Code: 6640 - Laboratory Equipment And Supplies
- NAICS Code: 334516 – Analytical Laboratory Instrument Manufacturing (Size Standard: 1,000 employees)
- Quantity: 1 Unit
- Delivery: Within 2-6 weeks after receipt of award.
- Set-Aside: None (This acquisition is NOT set aside for small business.)
- Response Due: April 27, 2026, at 9:00 am EDT
- Published: April 17, 2026
Submission & Evaluation
This is not a request for competitive proposals. However, responsible sources may submit a capability statement demonstrating their ability to meet all minimum technical requirements. Submissions should include technical specifications, pricing, delivery terms, and business size status. The government has identified the Bioruptor Pico sonication device as the only system meeting all requirements, with Hologic Sales and Service, LLC as the exclusive distributor. Offerors must be registered in SAM.gov.
Contact Information
Nicholas Capobianco Email: nicholas.capobianco@nih.gov